Author: Xin Hongbao, Zhu Guoshuai 

Publisher: College of Physics and Optoelectronic Engineering  

Date: November 4, 2024

Professors Xin Hongbao and Li Baojun from the College of Physics and Optoelectronic Engineering have achieved a significant milestone in neurooptical regulation, with their latest research published in the esteemed journal Light: Science & Applications. Their paper, titled Neural stimulation and modulation with subcellular precision by optomechanical bio-darts, explores innovative techniques for precise neural activation.

(Screenshot of the paper)

Breakthrough in Neural Regulation

The research presents a novel method that leverages optical micro-manipulation to achieve high-resolution neural stimulation. The team utilized optomechanical forces to create bio-darts from sunflower pollen grains, allowing for targeted and transient pressure application at the subcellular level. This innovative approach effectively activates mechanosensitive ion channels in neurons, enabling precise control over neuronal signaling and modulation.

Key Findings

The study’s findings demonstrate several groundbreaking capabilities:

- Subcellular Precision: The optomechanical bio-dart can stimulate specific neuronal structures, such as dendrites, axons, and somas.

- In Vivo Applications: Successful implementation of this technique for neural stimulation in larval zebrafish showcases its potential for live subjects.

- Multifunctionality: Beyond stimulation, these bio-darts can also serve as platforms for drug delivery, enhancing opportunities for multifunctional neural modulation.

Research Significance

This advancement addresses the challenges of developing biocompatible techniques for precise neuronal modulation, offering insights into neuronal dysfunction and potential treatments for neurodegenerative diseases. By enabling fine-tuned control over neural activity, this research paves the way for future studies on neuronal plasticity and neuromodulation.

Dr. Zhu Guoshuai, a doctoral student at the Institute of Nanophotonics, is the first author of the paper, and Professors Xin Hongbao and Li Baojun are co-corresponding authors. The study also includes contributions from Professor Zhang Li at the Guangdong Hong Kong Macao Central Nervous Regeneration Research Institute.

For those interested in reading more about this groundbreaking research, you can access the paper [here] (https://www.nature.