Publisher: First Affiliated Hospital  

Date: July 12, 2024

The team led by Professor Xu Anding, Associate Researcher Lu Dan, and Associate Researcher Mai Hongcheng from the First Affiliated Hospital has made significant strides in understanding the transport of small extracellular vesicles (sEVs) related to hypoxia and circular RNAs (circRNAs). 

On June 26, 2024, their research paper titled FUS Selectively Facilitates CircRNAs Packing into Neural Small Extracellular Vesicles under Hypoxia Condition was published online in the prestigious journal Advanced Science. The First Affiliated Hospital is recognized as the primary completion unit for this study.

(Screenshot of the paper)

The paper features contributions from postdoctoral fellows Zang Jiankun (Foshan First People's Hospital), Wu Yousheng, Su Xuanlin, and Cai Kaiwei, who are co-first authors. The corresponding authors include Associate Researcher Lu Dan, Professor Xu Anding, and Associate Researcher Mai Hongcheng, with collaboration from Sun Yat-sen Memorial Hospital of Sun Yat-sen University.

This study focuses on hypoxic neurons and provides an in-depth exploration of how hypoxia-related circRNAs are transmitted and encapsulated into sEVs. The research highlights the role of RNA binding proteins (RBP) and stress granules (SG) in this molecular process, utilizing a variety of advanced techniques.

Original Source:  

Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, et al. Hongcheng Mai, Anding Xu & Dan Lu. (2024). FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron. Advanced Science, 26:e2404822.  

[Read the full paper here] (https://onlinelibrary.wiley.com/doi/10.1002/advs.202404822).