Publisher: Guangdong-Hong Kong-Macao Central Nervous System Regeneration Research Institute

Date: May 23, 2024

In a groundbreaking discovery, the research team led by Yang Su and Li Xiaojiang at the prestigious Guangdong-Hong Kong-Macao Central Nervous Regeneration Research Institute has uncovered a previously unknown Huntington protein degradation pathway exclusive to primates.

Published on May 17th in the esteemed journal Science Advances, their paper titled TRIM37: A Key E3 Ligase for Huntingtin and its Role in Spinal Regeneration in Huntington's Disease provides unprecedented insights into the molecular mechanisms behind the specific death of striatal neurons observed in Huntington's disease (HD).

（Screenshot of the paper）

The collaborative efforts of doctoral students Qin Yiyang, Chen Laiqiang, and master's student Zhu Wenzhen from Jinan University have been instrumental in this research endeavor, with Yang Su and Li Xiaojiang serving as co-corresponding authors. The study's success has been bolstered by funding from key sources, including the national research and development program, National Natural Science Foundation of China project, Guangdong Provincial Department of Science and Technology project, and the Guangdong Provincial Key Laboratory of Non-human Primate Animal Model Research, among others.

For further details on this groundbreaking study, the full paper can be accessed at: (https://www.science.org/doi/10.1126/sciadv.adl2036). This research not only deepens our understanding of Huntington's disease but also holds promise for the development of innovative therapeutic interventions to combat this debilitating condition.