Sept. 5, 2023 

Source: Guangdong-HongKong-Macau lnstitute of CNS Regeneration

Translator: HE Qijin

Researchers including JNU Profs. Yan Sen and Tu Zhuochi successfully used the CBE4max system to generate an immunodeficient monkey that supports tumor growth. These immunodeficient monkeys show tremendous potential as valuable tools for advancing biomedical and translational research. The research results, titled Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing, were published on Sept. 4 in the journal Signal Transduction and Targeted Therapy (IF=39.3)  (https://www.nature.com/articles/s41392-023-01544-y).

（Screenshots of the paper）

Yan and Tu, researchers in the Guangdong-Hong Kong-Macao lnstitute of CNS Regeneration at JNU, are the corresponding authors. Dr. Zheng Xiao and Dr. Huang Chunhui of JNU are the first authors. This study received strong support from the National Key Research and Development Program of China, the National Natural Science Foundation of China, the Guangzhou Key Research Program on Brain Science, JNU, the Guangdong Department of Science and Technology, the Guangzhou Municipal Science and Technology Bureau, and the Guangdong Key Laboratory of Non-Human Primate Research.