Date: March 21, 2022

Source: School of Medicine

Associate Prof. Wan Qinli of the Department of Pathogen Biology in JNU's School of Medicine has published a paper in Nature Communications (IF=14.9). The paper, Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans, reports the lipid accumulation of a nematode model of C. elegans raised on a high-fat diet, which can transmit the lipid accumulation signal to their multigenerational progeny, enabling them to accumulate lipid without being raised on a high-fat diet. It also reveals that histone H3K4me3 modification mediates this transgenerational inheritance.

(Screenshot of the paper)

The first authors are Wan and Meng Xiao, a JNU postgraduate student. The corresponding author is Prof. Zhou Qinghua of JNU's Biomedical Translational Research Institute.

Link to paper: https://doi.org/10.1038/s41467-022-28469-4.